Fluoxetine- and Sertraline-Related Hair Loss in a Teenager: A Case Report

摘要

Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed antidepressants. All SSRIs have occasionally been associated with alopecia or hair loss. There might be differences in the risk of alopecia between the various SSRIs, and the risk might be higher in women than in men. The pathological mechanism of hair loss due to psychotropic medications has not yet been fully elucidated. Here, we present an adolescent female with no personal and family history of alopecia, who developed common alopecia with consecutive fluoxetine and sertraline treatments. The hair loss stopped with a venlafaxine regimen. To our knowledge, this is the first report of hair loss due to both fluoxetine and sertraline, which then recovered with venlafaxine treatment. If a patient develops hair loss during SSRI treatment and the temporal relationship seems plausible, an adverse drug reaction should be suspected and changing the treatment to another antidepressant or possibly decreasing the dose should be considered.?ZETSelektif serotonin reuptake inhibit?rleri (SSRI) yayg?n olarak kullan?lan antidepresanlard?r. Tüm SSRI'lar ile ili?kili zaman zaman yayg?n sa? d?külmesi bildirilmi?tir. SSRI'lar?n sa? d?külmesi riskiyle ili?kili farkl? oranlar bildirilmi? ve riskin kad?nlarda daha fazla oldu?u belirtilmi?tir. Psikotroplar?n sa? kayb?na yol a?ma mekanizmas? henüz tamamen ayd?nlat?lamam??t?r. Bu olgu sunumunda, ilk olarak fluoksetin ve sonras?nda sertralin ba?lanmas?n?n ard?ndan ?zge?mi?inde ve aile ?yküsünde olmad??? halde, yayg?n sa? d?külmesi g?zlenen bir ergeni bildiriyoruz. Bizim bilgilerimize g?re bu olgu, hem fluoksetin hem de sertralin ile yayg?n sa? d?külmesi g?rülen, ard?ndan tedavisine venlafaksin ile devam edilen ve sa? d?külmesi duran ilk olgudur. SSRI tedavisi s?ras?nda hastada sa? kayb? geli?ir ve zamansal ili?ki olarak akla yatk?n g?rünürse, ila? yan etkisinden ?üphe edilmeli, ya doz dü?ürülerek ya da ba?ka bir antidepresana ge?ilerek tedaviye müdahale edilmelidir.