Interference of Extracts Obtained from Baccharis Coridifolia D. C. (Asteraceae-Astereae) Action of Antibiotics

摘要

The family Asteraceae is the most numerous group within the Angiosperms. Plants from this family are studied for their chemical composition and biological activity. In these studies, the allelopathic, antimicrobial, cytotoxic and anti-inflammatory effects are highlighted. The aim of this study was to evaluate the action of the aqueous (AF1) and the oily (OF2) fractions obtained from the ethanol extract of Baccharis coridifolia D. C. on the antimicrobial activity of antibiotics used in clinical treatment. The drugs chloramphenicol (30 μg), norfloxacin (10 μg), sulfamethoxazole / trimethoprim (75/23 μg), vancomycin (30 μg) and amoxicillin (10 μg) were saturated with the fractions AF1 and OF2, and used pure for further comparison. The strains Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 were used. The results showed that both fractions interfered on the activity of the antibiotics tested. Synergistic, antagonistic or indifferent behavior was observed in the interactions, with various degrees of susceptibility to the antibiotics tested. These results show that the use of products derived from plants can, in some cases, interfere with the effectiveness of antibiotics during clinical therapy.