Lipid associated antioxidants: arylesterase and paraoxonase-1 in benign prostatic hyperplasia treatment-na?ve patients

摘要

Background Oxidative stress and antioxidants have been implicated in many diseases including prostate cancer and benign prostatic hyperplasia (BPH). Lipid peroxidation contributes to oxidative stress. However, new and emerging antioxidants such as paraoxonase 1 (PON1) and arylesterase (ARE) associated with lipoprotein peroxidation have not been examined in BPH patients. PON1 and ARE, a high-density lipoprotein (HDL) cholesterol-bound enzyme system of antioxidants, protect low-density lipoprotein (LDL) cholesterol and HDL from oxidation by hydrolysis. The study primarily determined paraoxonase (PON1) and ARE activities in BPH treatment-na?ve patients. Materials and methods Sixty newly diagnosed patients (treatment-na?ve) alongside 30 apparently healthy controls were recruited. Blood examinations included lipid profile (total cholesterol, triglycerides, LDL, HDL), glutathione peroxidase, PON1, ARE, and prostate specific antigen (PSA). Prostate volume and International Prostate Symptoms Score (IPSS) were determined. Results PSA was significantly different between patient and control groups ( P ??0.05), ARE was significantly lower in the patient group (61.31?±?21.76/49.30?±?19.82?ng/mL; P ?=?0.0098). No correlation was established between antioxidants and the lipid profile except for the LDL and PON1 patient group (r?=?0.1486, P ?=?0.0374). Similarly, a weak correlation was also established between PSA and LDL in the patient group (r?=?–0.275, P ?=?0.033). PON1/HDL ratio was not significantly different. However, the ARE/HDL ratio was significantly lower in the patient group ( P ?