Two Women Presenting Worsening Cutaneous Ulcers during Pregnancy: Diagnosis, Immune Response, and Follow-up

摘要

Two pregnant patients (PP) presenting cutaneous ulcers were referred to our outpatient clinics at Instituto de Pesquisas Clínicas Evandro Chagas (IPEC)–Fiocruz. The first patient (PP1, 24 years old) had an ulcer above the knee (35×25 mm). The second patient (PP2, 25 years old) presented an ulcer (22×17 mm) on the left arm. Lesion onset occurred approximately 2 months earlier in both patients, and both were 2–3 months pregnant. As they lived in areas endemic for American cutaneous leishmaniasis (ATL) and sporotrichosis (SP), specific tests for ATL and SP (lesion biopsies: histopathology, immunohistochemistry [IHC], and parasite/fungi/bacteria isolation; peripheral blood: serology) were performed. Routine pregnancy screenings were done, and blood counts and biochemistry were within the normal range.