Intrinsic and extrinsic drivers of transmission dynamics of hemorrhagic fever with renal syndrome caused by Seoul hantavirus

摘要

Seoul hantavirus (SEOV) infections are common in Europe and Asia where a considerably high seroprevalence among the population is found. However, only relatively few hemorrhagic fever with renal syndrome (HFRS) cases are reported. Comprehensive epidemiological data is necessary to study the patterns and drivers of this underestimated disease. Here, we analyzed rodent host surveillance and seroprevalence data from 1998 to 2015 for disease outbreaks in Huludao City, one of the typical SEOV-endemic areas for HFRS in China. Our mathematical models quantified the drivers on HFRS transmission and estimated the epidemiological parameters. Our study provides an understanding of its ecological process between intrinsic and extrinsic factors, human-rodent interface and disease dynamics.