Spike-Based Bayesian-Hebbian Learning of Temporal Sequences

摘要

Author Summary From one moment to the next, in an ever-changing world, and awash in a deluge of sensory data, the brain fluidly guides our actions throughout an astonishing variety of tasks. Processing this ongoing bombardment of information is a fundamental problem faced by its underlying neural circuits. Given that the structure of our actions along with the organization of the environment in which they are performed can be intuitively decomposed into sequences of simpler patterns, an encoding strategy reflecting the temporal nature of these patterns should offer an efficient approach for assembling more complex memories and behaviors. We present a model that demonstrates how activity could propagate through recurrent cortical microcircuits as a result of a learning rule based on neurobiologically plausible time courses and dynamics. The model predicts that the interaction between several learning and dynamical processes constitute a compound mnemonic engram that can flexibly generate sequential step-wise increases of activity within neural populations.