Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats

摘要

Author summary As neuropsychiatry begins to leverage the power of computational methods to understand disease states and to develop better therapies, it is vital that we acknowledge the trade-offs between model complexity and performance. We show that computational methods can elucidate a neural signature of feeding behavior and we show how these methods could be used to discover neural patterns related to other behaviors and reveal new potential therapeutic targets. Further, our results help to contextualize both the limitations and potential of applying computational methods to neuropsychiatry by showing how changing the data being used to train predictive models (e.g., population vs. individual data) can have a large impact on how model performance generalizes across time, internal states, and individuals.