Biodegradation, Bioactivity and In vivo Biocompatibility Analysis of Plasma Electrolytic Oxidized (PEO) Biodegradable Mg Implants

摘要

In this paper, a plasma electrolytic oxidation (PEO) coating was prepared on AZ91 magnesium (Mg) implant to improve its degradation resistance, bioactivity and biocompatibility. The phase composition and surface morphology of the samples were characterized using X-ray diffraction (XRD) and scanning electron microscope (SEM). The corrosion rate and the bioactivity behavior of the samples were investigated via electrochemical measurements and immersion tests in simulated body fluid (SBF). The biocompatibility of samples was evaluated both in vitro and in vivo . To performed in vitro examinations, L-929 cells were cultured on both coated and uncoated substrates, and for the in vivo study, samples were implanted into the greater trochanter of rabbits as our animal model. The results showed that the PEO coating enhanced the corrosion resistance and in vitro and in vivo biocompatibility of AZ91 Mg implants.