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Nutraceutical with Anti-Inflammatory Activity for the Management of Airway Remodeling in Bronchial Asthma: Kalanchoe integra Var. Crenata (Andr.) Cuf Leaf Extract

机译:具有抗炎活性的营养保健品,用于支气管哮喘气道重塑的管理:Kalanchoe integra Var。 Crenata(Andr。)Cuf叶子提取物

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Background: Kalanchoe integra is widely used in folklore medicine as an antiasthmatic agent. Previous studies have shown the ameliorating effect of Kalanchoe integra leaf extract [KILE] on bronchial hyperesponsiveness and inflammation. Further, the stabilizing effect of Kalanchoe sp on mast cell degranulation, suggests that Kalanchoe species are suitable candidates for allergic asthma therapy. This study is designed to investigate the anti-asthmatic potential of KILE and monitor the accompanying histopathological and immunobiochemical changes that occur in an animal model of bronchial asthma using ovalbumin sensitized guinea pigs. Method: Thirty male guinea pigs were divided into five groups of six animals each. Bronchial asthma was simulated in guinea pigs using ovalbumin. Both low dose (300 mg/kg) and high dose extract (900 mg/kg) were administered daily for 42 days. Prednisolone (2.5 mg/kg) was the standard drug used. Results: Guinea pigs in all KILE treated groups maintained the integrity of their airway structures: bronchial folds and walls, alveoli, alveolar ducts and sacs. KILE and prednisolone caused a reduction in immune parameters (p 0.001), extent of bronchoconstriction, bronchial wall thickness and goblet cell accumulation in the sensitized guinea pigs. Conclusion: This study demonstrates the anti-asthmatic potential of KILE during prolonged administration by the oral route.
机译:背景:Kalanchoe积分在民俗医学中被广泛用作抗哮喘药。先前的研究表明,Kalanchoe整合叶提取物[KILE]对支气管过敏反应和炎症有改善作用。此外,Kalanchoe sp对肥大细胞脱粒的稳定作用表明,Kalanchoe种适合用于过敏性哮喘治疗。这项研究旨在调查KILE的抗哮喘潜力,并监测使用卵清蛋白致敏的豚鼠在支气管哮喘动物模型中发生的伴随的组织病理学和免疫生物化学变化。方法:将三十只雄性豚鼠分成五组,每组六只。使用卵清蛋白在豚鼠中模拟支气管哮喘。低剂量(300 mg / kg)和高剂量提取物(900 mg / kg)每天服用42天。泼尼松龙(2.5 mg / kg)是使用的标准药物。结果:所有KILE治疗组的豚鼠均保持其气道结构的完整性:支气管褶皱和壁,肺泡,肺泡管和囊。 KILE和泼尼松龙导致致敏的豚鼠免疫参数(p 0.001),支气管收缩程度,支气管壁厚度和杯状细胞积累减少。结论:本研究证明KILE在口服长期服用期间具有抗哮喘作用。

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