IN VITRO BIORESORBABILITY OF CHELATE-SETTING CEMENTS WITH VARIOUS CALCIUM-PHOSPHATE PHASES

摘要

We have developed calcium-phosphate cement (CPC) that can be formed into any desired shapes during an operation. The novel hydroxyapatite (HAp) and tricalcium phosphate (TCP) cements set on the basis of chelate-bonding ability of inositol phosphate (IP6). In the present study, we evaluated dissolution rate of various CPCs under conditions of acetic acid buffer solution at pH5.5. The concentration of calcium ions released from the CPCs with HAp, β -TCP and α -TCP phases in the acetic acid buffer solution was continuously measured using a calcium ion meter. The dissolution rate of samples decreased in order of α -TCP > β -TCP > HAp derived from wet process (wet-HAp) > commercially-available HAp.