Abstract Context: Since antiquity, Pistacia lentiscus L. (Anacardiaceae) fruit oil (PLFO) has been used as a remedy for primary health care such as burn treatment. Objective: This study assesses the healing effect of PLFO on CO2 laser fractional burn in a rat model. Materials and methods: The study was carried out on 18 adult male Wistar rats. A second-degree laser burn (wound area?=?2.2?cm2) was inflicted in the dorsal region by the application of CO2 fractional laser within the following parameters; Energy level: 25?MJ and Depth level: 4. After applying laser, the rats were divided into three groups: the first was treated with saline solution, the second with a reference cream ‘CYTOL BASIC?’ (0.13?μg/mm2) and the third with PLFO (0.52?μL/mm2). All treatments were topically administered for eight days. The healing effect was assessed using macroscopic, histological and biochemical parameters. Results: After eight days, the higher percentage of wound healing contraction was observed among the PLFO-treated group (100%) followed by the ‘CYTOL BASIC?’ treated group (61.36%) and untreated group (32.27%). During the treatment, the PLFO-treated group showed less erythema, less crusting/scabbing, higher general wound appearance scores and a high content of collagen (220.67?±?7.48?mg/g of tissue) than the other groups. Discussion and conclusion: The current study has shown, for the first time, the healing effect of PLFO on CO2 laser fractional burn. Their wound healing effect could be attributed to their antimicrobial, anti-inflammatory and antioxidant effects.
展开▼
