Crataegus Aronia protects and reverses vascular inflammation in a high fat diet rat model by an antioxidant mechanism and modulating serum levels of oxidized low-density lipoprotein

摘要

Context: Crataegus aronia (Willd.) Bosc (Rosaceae) (syn. Azarolus L) is traditionally used to treat cardiovasculardisorders.Objectives: To investigate C. aronia protection against a high-fat diet (HFD)-induced vascular inflammationin rats.Materials and methods: Wistar Male rats (180–220 g) were divided (n ? 10/group) as control fed a standarddiet (STD), STD t C. aronia (200 mg/kg, orally), HFD, HFD t C. aronia and HFD post-treated with C.aronia. Simvastatin (20 mg/kg) was co- or post-administered as a positive control drug. HFD was given for8 weeks, and all other treatments were administered for 4 weeks.Results: Most significantly, co-administration of C. aronia to HFD-fed rats reduced the thickness of aortatunica media (90 ± 5 vs. 160 ± 11.3 mm) and adventitia (54.3 ± 3.8 vs. 93.6 ± 9.4 mm). It also lowered proteinlevels of TNF-a (0.51 ± 0.15 and 0.15 ± 0.16 vs. 0.1 ± 0.09%) and IL-6 (0.52 ± 0.19 vs. 1.0 ± 0.2%) in theiraorta or serum (5.9 ± 0.91 vs. 12.98 ± 1.3 ng/mL and 78.1 ± 6.7 vs. 439 ± 78 pg/mL, respectively). It also loweredall serum lipids and increased aorta levels of GSH levels (70.4 ± 4.0 vs. 40.7 mM) and activity of SOD(5.7 ± 0.7 vs. 2.9 ± 0.6 U/mg) and decreased serum levels of ox-LDL-c (566.7 ± 46 vs. 1817 ± 147 ng/mL).Such effects were more profound than all other treatments.Conclusions: C. aronia inhibits the HFD-induced vascular inflammation and its use in clinical trials isrecommended.