Studies on Rebamipide Loaded Gastroretentive Alginate Based Mucoadhesive Beads: Formulation & In-vitro, In-vivo Evaluation

摘要

Introduction: Oral route is the most common and convenient routeto deliver the drug. Many oral drug delivery systems were developed toimprove drug bio availability; gastro retentive drug delivery system is oneof them. Gastroretentive drug delivery system is the system in which adrug can remain in the gastric region for several hours in order to prolongits gastric residence time. The purpose of this work was to develop andevaluate rebamipide loaded gastro retentive alginate based muco adhesivebeads. Materials and Methods: Rebamipide loaded alginate beads wereprepared by ionotropic gelation and polyelectrolyte complexation method.Prepared beads were characterized for IR, DSC, SEM and evaluated fordissolution and stability studies. Results: The FTIR spectra revealed thatthere were no interaction between drug and excipients. The particle sizeanalysis showed that beads with 3% of sodium alginate were spherical inshape. The mucoadhesion study reveals that as concentration of alginateand carbopol 934 increases percentage of mucoadhesion also increases.Conclusion: From in-vivo study it was concluded that the preparedformulation showed better control on ulcer than that of pure rebamipide.Rebamipide was successfully formulated as gastroretentive floating andmucoadhesive alginate beads by using ionotropic gelation and polyelectrolytecomplexation method.