Formulation, Optimization and Characterization of Solid Dispersion of Glibenclamide

摘要

Aim: The aim of the present study was to increase the solubility and dissolutionof Glibenclamide. Materials and Methods: Various batches ofsolid dispersion of Glibenclamide using water soluble carriers such asPEG (PEG 4000 and PEG 1500), were prepared as per the design expert(8.0.5) to optimize the drug release profile using response surfacemethodology (Face centered central composite design). Results: DSCand FTIR were used to characterize the solid dispersions. No chemicalinteraction was found between Glibenclamide and polymers. F3 and F13was found to be optimized batch according to the Face centered centralcomposite design (FCCCD). Conclusion: Drug release was directly proportionalto the concentration of polymer used for the formulation of soliddispersion. Thus, Glibenclamide with PEG 4000 and PEG 1500 had fasterdissolution rate than Glibenclamide itself.