Use of Anopheles salivary biomarker to assess seasonal variation of human exposure to Anopheles bites in children living near rubber and oil palm cultivations in C?te d'Ivoire

摘要

Environmental changes related to agricultural practices and activities can impact malaria transmission. In the objective to evaluate this impact on the human-vector contact, the level of human exposure toAnophelesvector bites was assess by an immuno-epidemiological indicator based on the assessment of the human IgG antibody response to theAnopheles gambiaegSG6-P1 salivary peptide, previously validated as a pertinent biomarker.Two cross-sectional surveys were carried out in the dry and rainy season in three villages with intensive agricultural plantations (N'Zikro with rubber cultivation, Ehania-V5 and Ehania-V1 with palm oil exploitation) and in a control village without plantations (Ayébo). Overall, 775 blood samples were collected in filter papers from children aged 1 to 14?years-old for immunological analysis by ELISA. The IgG levels to the gSG6-P1 salivary peptide significantly differed between studied villages both in the dry and the rainy seasons (P?