Letter-to-the-Editor in response to “Tanton C, et al. Human papillomavirus (HPV) in young women in Britain: Population-based evidence ofthe effectiveness of the bivalent immunisation programme and burden of quadrivalent and 9-valent vaccine types. Papillomavirus Res. 2017 Jun;3:36-41.doi: 10.1016/j.pvr.2017.01.001.”

摘要

Samples in Natsal-2 were collected in a urine collection cup, whereas samples in Natsal-3 were collected with a specific device (Firstburst) that collects the first-void urine. It has been shown that Chlamydia organism load is 6 times higher in the Firstburst collected first-void urine compared to urine collected in a regular cup [3]. As the use of different collection techniques may impact the HPV load, we wish to understand whether a validation of the Firstburst versus the urine cup sample collection has been conducted prior to the analysis.