A Negative Correlation Between Hyperalgesia and Analgesia in Patients with Chronic Radicular Pain: Is Hydromorphone Therapy a Double-Edged Sword?

摘要

Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Yet, unconfirmed evidence suggests that chronic exposure to opioids may cause hypersensitivity to pain, a phenomenon known as opioid-induced hyperalgesia (OIH).