Comparison of the Effect of Tanacethum Parthenium, 5-Hydroxy Tryptophan, and Magnesium (Aurastop) versus Magnesium Alone on Aura Phenomenon and Its Evolution

摘要

None of the clinical trials on migraine conducted thus far have focused on the possibility to modulate the phenomenon of aura.Furthermore, whether proper management of aura results in a better control of the headache phase has been poorly investigated.In the setting of a single-center, pilot, clinical trial, we aimed at comparing the effects of Aurastop (a combination of tanacetumparthenium (150 mg extracted at 0.8% ? 1.2 mg di of active parthenolide), griffonia simplicifoila (20 mg of 5-hydroxy tryptophan),and magnesium (185 mg of magnesium pidolatum)) with those of magnesium alone (2.25 grams/tablet, corresponding to 184 mgof Mg++) in the treatment of acute attacks of migraine with aura. Between June 2017 and June 2018, 50 consecutive patients (27/23male/female; mean age, 31 [18–57] years) with at least 3 episodes of aura per year were included (t0). Participants were instructedto keep track of the following 4 episodes of migraine with aura (t1) and invited to assume (1) a tablet of Aurastop at the beginningof the following 2 episodes of aura and (2) a magnesium tablet alone at the occurrence of the third and fourth aura attacks. Fortyeightpatients (96.0%) had 50% reduction in aura duration when treated with Aurastop vs. 7 patients (14.0%) when treated withmagnesium alone (p 0.001); 48 patients (96.0%) had 50% reduction of aura-related disability when receiving Aurastop vs. 5patients (10.0%) when treated with magnesium alone (p 0.001); however, patients receiving Aurastop did not need to take painkillers in 35% of aura attacks vs. 3% when assuming magnesium (p 0.001). ,ese results support the hypothesis that Aurastopmight be effective in interfering with the phenomenon of aura and provide evidence that the clinical benefit attributable to thiscombination of molecules might be greater than that obtained with single compounds of proven effect on the biology of migraine.