The Science of Sample Management Enabling Discovery from Bench to Clinic

摘要

Within scientific discovery efforts, efficient and compliant tracking and movement of samples, whether chemical, biological, or clinical, are the primary goals of a sample management organization. Sample management practices have advanced significantly during the past 25 years, and the importance of growing and maintaining sample collections has been underscored by high-throughput screening in early drug discovery through to collection and storage of human clinical samples for future biological research in clinical development. Today’s sample management operations can range from centralized and highly automated robotic storage systems with complex data integration, to local manual storage with simple spreadsheets for inventory tracking, to (in more cases than may be admitted) the long-trusted combination of freezer, Sharpie-written label, and the scientist’s memory. Regardless of the selected sample management methodology, this discipline remains necessary and imperative for enabling science from drug discovery to the clinic.