Relationship between H. pylori infection and microalbuminuria in type 2 diabetic patients

摘要

Objective: The aim of this study was to investigate the relationship between helicobacter infection and occurrence of microalbuminuria (a marker of diabetic nephropathy) in type 2 diabetic patients. Background: The incidence and prevalence of type 2 diabetes mellitus is one of the most critical problems in the healthcare system. Diabetes is a fast-growing health problem in Egypt with a significant impact on morbidity, mortality, and health care resources. Currently, the prevalence of type 2 diabetes (T2D) in Egypt is around 15.6% of all adults aged 20 to 79. Patients and Methods: Cross sectional study was conducted on50 type-2 diabetic patients that invited to Group I: Included 25 patients of type 2 diabetes mellitus with microalbuminuria, and Group II: Included 25 patients of type 2 diabetes mellitus without microalbuminuria attending to Banha Educational Hospital-EGYPT for diabetic care. In addition, Twenty healthy individuals as control group. The study was done during the period from January 2015 to December 2015. Subjects were submitted to the history taking, physical examination as well as routine and special investigations . Results: no significant difference between case and control groups regarding age and BMI (p value> 0.05). On contrast, there was high significant difference regarding hypertension, SBP /mmhg and DBP /mmhg and all studied laboratory characteristics except Urea and Creatinine . There was significant relation between group I and group II regarding age, BMI and all studied laboratory except Creatinine (mg/dl) . no significant correlation (p value > 0.05) between microalbuminuria with clinical data and all studied laboratory characteristics except 24h urinary ptn (mg/d). Results indicated that non-significant correlation (p value >0.05) was observed between CIMT and studied microalbuminuric patients with positive HPIgG. Conclusions: Results of concluded that H.P. infection is significantly prevalent in type 2 diabetes patients with microalbuminuria (64%) compared to non-microalbuminuric diabetic patients (28%). In H.P. IgG positive diabetic patients with microalbuminuria (16/25%), microalbuminuria is not significantly correlated with the studied clinical, CIMT and laboratory data except with 24 hrs urinary patients (r=1, p=0.00). moreover, the validity of microalbuminuria for detection of H.P. IgG in the studied type 2 diabetes patients is weak at cut off level of 95.0 (sensitivity 56.2, specificity, 44.4, p value = 0.699).