Immunomodulatory and prophylactic properties of some selected Nigerian higher fungi

摘要

The prophylactic potentials of five Nigerian higher fungi – Pleurotus tuber-regium, Pleurotus pulmonarius, Termitomyces robustus, Fomes lignosus, Lentinus subnudus and their combination in equal proportion (mixture extract) were investigated. The ethanolic fungi extracts were tested on sets of albino rats ( Rattus norvegicus ) infected with selected bacteria ( Escherichia coli, Staphylococcus aureus, Salmonela typhi, Pseudomonas aeruginosa, Streptococcus feacalis and Bacillus subtilis. Extracts were orally administered at 1.0ml concentration against 0.1ml/cfu microbial suspension intraperitoneally. Survival rates of the experimental rats were monitored. Mixture of these extracts exhibited significant level of prophylactic effect against all the bacteria in the host organisms.