Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells

Minfeng Shu; Yuxi Zhou; Wenbo Zhu; Sihan Wu; Xiaoke Zheng; Guangmei Yan

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Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells

机译：存活途径IL-6 / JAK2 / STAT3的激活在霍乱毒素诱导的C6恶性神经胶质瘤细胞分化过程中有助于胶质纤维酸性蛋白的诱导

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Differentiation-inducing therapy has been proposed to be a novel potential approach to treat malignant gliomas. Glial fibrillary acidic protein (GFAP) is a well-known specific astrocyte biomarker and acts as a tumor suppressor gene (TSG) in glioma pathoge

机译：已经提出分化诱导疗法是治疗恶性神经胶质瘤的一种新的潜在方法。胶质纤维酸性蛋白（GFAP）是众所周知的特异性星形胶质细胞生物标志物，在神经胶质瘤的病理过程中起着抑癌基因（TSG）的作用。

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《Molecular oncology.》 |2011年第3期|共8页
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Minfeng Shu; Yuxi Zhou; Wenbo Zhu; Sihan Wu; Xiaoke Zheng; Guangmei Yan;
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中图分类肿瘤学;
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1. Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma. [J] . Roymans D, Grobben B, Claes P, Cell biology international. . 2001,第5期

机译：蛋白质酪氨酸激酶对腺苷酸环化酶和磷脂酰肌醇3-激酶的依赖性调节在诱导大鼠c6神经胶质瘤分化后激活神经胶质原纤维酸性蛋白的表达。
2. Cyclic AMP-mediated induction of the glial fibrillary acidic protein is independent of protein kinase A activation in rat C6 glioma. [J] . Anciaux K, Van Dommelen K, Nicolai S, Journal of Neuroscience Research . 1997,第4期

机译：环AMP介导的胶质纤维酸性蛋白的诱导独立于大鼠C6神经胶质瘤中的蛋白激酶A激活。
3. Phosphatidylinositol 3-kinase activity is required for the expression of glial fibrillary acidic protein upon cAMP-dependent induction of differentiation in rat C6 glioma. [J] . Roymans D, Vissenberg K, De Jonghe C, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2001,第2期

机译：在大鼠C6胶质瘤中cAMP依赖性诱导分化后，神经胶质原纤维酸性蛋白的表达需要磷脂酰肌醇3-激酶活性。
4. The role of nucleoside diphosphate kinase and phosphatidylinositol 3-kinase in the expression and cellular localization of the glial fibrillary acidic protein upon cAMP-induced differentiation of rat C6 glioma. [D] . Roymans, Dirk. 2000

机译：cAMP诱导大鼠C6胶质瘤分化后核苷二磷酸激酶和磷脂酰肌醇3-激酶在神经胶质原纤维酸性蛋白的表达和细胞定位中的作用。
5. Activation of a pro‐survival pathway IL‐6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin‐induced differentiation of C6 malignant glioma cells [O] . Minfeng Shu, Yuxi Zhou, Wenbo Zhu, 2011

机译：霍乱毒素诱导的C6恶性神经胶质瘤细胞分化过程中激活的生存途径IL-6 / JAK2 / STAT3有助于神经胶质纤维酸性蛋白的诱导
6. Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Neurodegeneration [O] . Krishnan Sriram, Stanley A. Benkovic, Meleik A. Hebert, 2004

机译：与星形胶质细胞中的GP130相关细胞因子和jak2 / stat3途径的激活在神经变性的1-甲基-4-苯基-1,2,3,6-四氢吡啶模型中的胶质纤维酸性蛋白质的上调前调节

Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells

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