Formulation, characterization and ex-vivo permeation studies on gentamicin-loaded transdermal patches based on PURASORB polymers

摘要

Topical administration of gentamicin, an aminoglycoside antibiotic commonly used for treatment of bacterial infections, is limited by toxicity and membrane impermeability. The purpose of this study was to develop an alternative non-invasive, convenient and cost-effective drug delivery system for enhanced skin delivery of gentamicin. Thepatcheswereformulated by solvent evaporation technique using PURASORB®polymersand evaluated for drug content, thermal properties, physicochemical performance, stability, skin irritability andex-vivodrug permeation through rat skin using a modified Franz diffusion cell. The DSC results indicate absence of strong interaction between gentamicin and the polymers. Theformulationsshowedgooddrug encapsulation,stability, physicochemical properties, tolerability on rat skin andex-vivodrug permeation through rat skin.Compared with a commercially available gentamicin sulphate cream the transdermal patches gave higherex-vivoskin permeation through rat skinwith patches of PURASORB®PL 32 showinghighestpermeationflux(5.161 µg/cm2.h) and permeation coefficient (1.032× 10-6cm/h). The results of this study indicates that patches of PURASORB®PL 32 represent a new delivery system for enhnaced skin delivery of gentamicin.