Thirty years of Oncogene

摘要

The paper by Stehelin et al.] published in Nature in 1976 entitled 'DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA,' which demonstrates that the src sequences of the Rous sarcoma virus are derived from the host genome marks a symbolic beginning or an early major triumph and high point in molecular oncology. This work culminated in Michael Bishop and Harold Varmus being awarded the 1989 Nobel Prize in Physiology and Medicine and spawned the promise of the study of oncogenes in delineating the mechanisms of tumorigenesis. The enthusiasm generated by this and allied pioneering works from that era led to the creation of Oncogene 30 years ago.