Potassium carbonate mediated one-pot synthesis and antimicrobial activities of 2-alkoxy-4-(aryl)-5 H -indeno[1,2- b ]pyridine-3-carbonitriles

摘要

2-Alkoxy-4-(aryl)-5 H -indeno[1,2- b ]pyridine-3-carbonitriles ( 3a-e and 4a-e ) were synthesized via multicomponent reaction from 2-aryl-methylidineindan-1-ones ( 1a-e ), malononitrile and K 2CO 3 in ethanol and/or methanol. The structures of obtained compounds ( 3a-e and 4a-e ) were characterized using the spectroscopic methods (NMR, IR) and elemental analysis. Addition, the in vitro antimicrobial activities of compounds ( 3a-e ) were tested against the five human pathogenic bacteria. Penicillin G and Ceftriaxone antibiotics were used as positive control. The results were given as MIC values (minimum inhibition concentration), and compounds 3b-d showed very high activity against Escherichia coli 111.