Neural Stem Cells Transplantation Promotes Brain Repair after Chronic Experimental Allergic Encephalomyelitis in Rat

摘要

The recent studies have showed neural stem cells (NSCs) transplantation promoted repair and functional recovery of chronic experimental allergic encephalomyelitis (EAE) animal model for MS based on the concept of cell replacement. In the present study, NSCs were transplantated into each lateral ventricle of rats at 10 days and sacrificed at 60 days after EAE immunization. We found that NSCs transplantation significantly reduced the clinical signs, suppressed brain inflammation and improved density of myelin. Transplanted NSCs differentiated into neurons and oligodendrocytes. Moreover, the number of endogenous neurons and oligodendrocytes in the rats treated with NSCs was significantly higher compared to the rats with saline. These results suggest an important neuroprotective role for NSCs that can potentially be exploited in cell-based therapeutic approaches for EAE.