Synthesis of N-Alkyl-2-thiomethyl Benzimidazoles: A Green Approach

摘要

A green approach for the synthesis of N-alkyl-2-thiomethyl benzimidazoles2(R=CH3, C2H5, CH2Ph) under different conditions has been developed from N-alkyl-2-chloromethyl benzimidazole (i.e., CH3, C2H5, CH2Ph)1by reaction with thiourea by physical grinding, or by using green solvents like ethanol and PEG-600, or by using microwave irradiation technique.