Synthesis ofβ-Amino Carbonyl Compoundsviathe Iodine-Alumina Catalyzed Three-Component Coupling Reaction under Microwave Irradiation

摘要

Iodine-alumina was employed as a catalyst in the coupling reactions of aldehydes, enolizable ketones, or 1,3-dicarbonyls with methyl carbamate or aromatic amines under microwave irradiation to affordβ-amino carbonyl compounds in good-to-excellent yields. The key features of this environmentally friendly methodology are its operational simplicity, mild reaction conditions, and less reaction time.