Pathogenesis of Autoimmune Diseases: A short Review

摘要

Autoimmunity is characterized by the reaction of cells (autoreactive T-lymphocytes) or products (autoantibodies) ofthe immune system against the organism’s own antigens(autoantigen). It may be part of the physiological immuneresponse (natural autoimmunity) or pathologically induced, whichmay eventually lead to development of clinical abnormalities(autoimmune disease). Different mechanisms are involved inthe induction and progression of autoimmunity. These includegenetic or acquired defects in immune tolerance or immuneregulatory pathways, molecular mimicry to viral or bacterialprotein, an impaired clearance of apoptotic cell material. A Autoimmunity, due to copious production of autoantibodies andautoreactive cells. The aim of the present article is to review onthe pathogenesis of autoimmune diseases.