Objective: To ascertain the role of serum potassium levels in predicting clinical outcomes in diarrhea-associated hemolytic uremic syndrome (HUS D+). Methods: We reviewed clinical and laboratory data from HUS D+ patients at our tertiary care institution from 2001 to 2008. Serum potassium concentration at presentation and during the acute phase of acute renal failure were recorded and related to laboratory parameters and clinical outcomes. Results: 15 HUS D+ cases were identified. E. coli 0157:H7 was found in 9/15 cases (70%). Potassium levels were not predictive of clinical outcomes. Normal serum potassium levels were found in the majority of patients. Potassium levels <3.6 mmol/L were evident at presentation in 3/15 patients (23%), and no patient manifested hyperkalemia even when creatinine levels were concurrently increase. Conclusions: This study suggests the presence of vigorous compensatory mechanisms in the homoestasis of serum potassium levels during HUS D+ disease since neither the increase stool volumes associated with diarrhea nor the presence of renal failure resulted in clinically significant changes in serum potassium levels.
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机译:目的:确定血清钾水平在腹泻相关溶血性尿毒症综合征(HUS D +)的临床预后中的作用。方法:我们回顾了2001年至2008年三级医疗机构HUS D +患者的临床和实验室数据。记录了急性肾功能衰竭发作时和急性期的血清钾浓度,并与实验室参数和临床结果相关。结果:鉴定出15例HUS D +病例。在9/15例中发现了大肠杆菌0157:H7(70%)。钾水平不能预测临床结果。大多数患者血清钾水平正常。在3/15患者中,钾水平<3.6 mmol / L明显(23%),即使肌酐水平同时升高,也没有患者表现出高钾血症。结论:这项研究表明在HUS D +疾病期间血清钾水平的稳态中存在有力的补偿机制,因为与腹泻相关的大便量增加和肾功能衰竭的存在均不会导致血清钾水平的临床显着变化。
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