Introduction Fever is a cardinal manifestation of both autoinflammatory disease and infection. Distinguishing the two is a familiar challenge to the rheumatologist. This case report describes a young female presenting with recurrent fevers, rash and inflammatory arthritis. The case illustrates the importance of a careful travel and social history in the diagnosis and management of a patient presenting with recurrent fevers, particularly in an era of globalisation and air travel. Case description A 19-year-old Caucasian female presented to her local district general hospital with episodic fevers, rash, arthralgia, and abdominal pain. Past medical history included autoimmune liver disease, treated with azathioprine. She had no relevant family history, took no medications other than azathioprine, was a non-smoker and had no allergies. On presentation she was pyrexic with a temperature of 40?°C, and tachycardic (120bpm), with a BP of 108/59. She was synovitic in her wrists, knees and ankles. Pustular skin lesions were noted on the lower limbs, spreading to the groin, upper limbs and the face, and evolving into haemorrhagic bullae. Baseline bloods including cultures, and skin swabs were taken. Despite broad-spectrum antimicrobials and acyclovir, she continued to spike temperatures. Her symptoms briefly resolved on two occasions before recurring. Blood cultures and skin swabs were sterile and varicella PCR negative. She had high acute-phase reactants with a CRP of 238 and a ferritin of??1000. Autoimmune screen was positive for only anti-smooth muscle antibodies. The lack of response to anti-microbials and elevated ferritin raised suspicion of autoinflammatory pathology and prompted inpatient transfer to a tertiary rheumatology service. After transfer further investigations included a PETCT which demonstrated splenomegaly (25cm) with multiple metabolically active lesions. Three pieces of further history were elicited: (1) Four weeks prior to symptom onset, the patient reported a new sexual partner; (2) The patient has a pet cat which frequently scratched her legs, and; (3) She travelled to southern Spain four months prior to admission, and regularly walked her tick-infested grandparent’s dog through shrubland. She subsequently underwent screening for syphilis, HIV and gonococcus, molecular testing for Bartonella species, and serological assessment for tick-borne illnesses. She was positive for non-Lyme Borrelia species. A diagnosis of tick-borne relapsing fever (TBRF) was made, and treatment with doxycycline induced a rapid clinical response. Discussion Autoinflammatory diseases are characterised by recurrent episodes of inflammation due to defects in innate immunity. The absence of autoantibodies means recognition of clinical phenotype is crucial. In this patient, the presence of synovitis, high fevers, raised inflammatory markers and serum ferritin fit with adult-onset Still’s disease (AOSD). However, the rash was atypical. The rash in AOSD is salmon-pink, non-pruritic and typically occurs in the upper arms, abdomen and thighs. Additionally, although the spleen is often enlarged, focal lesions are rare. Infections were considered, particularly with background immunosuppression and liver disease. Negative cultures and failure to improve with antibiotics suggested a non-infectious cause. Detailed history identified risk factors for infections undetected by standard microbial tests. Disseminated gonococcal infection can present with pustular acral rash and asymmetric polyarthralgia for which PCR is standard diagnosis. Bartonellosis or cat-scratch disease usually presents 3-12 days after a scratch with tender local unilateral lymphadenopathy, malaise and fever. Bacillary angiomatosis can occur in immunocompromised patients and can present with subcutaneous nodules which haemorrhage or ulcerate. Bartonella is a fastidious gram-negative rod that requires special conditions for culture so is not routinely performed. There is no commercial serology test, so the specimen was sent to Porton Down for PCR, which was negative. A diagnosis of TBRF was reached due to exposure to ticks during travel to southern Spain and positive non-Lyme Borrelia serology. The species of tick found in this region are Ixodes Ricinus and Ornithodoros which are carriers of Borrelia and Babesia. TBRF’s incubation period is 3-18 days and presents with fever, arthritis, rash, abdominal pain and hepatosplenomegaly. Symptoms are episodic with periods of remission. The patient’s symptomatology was consistent with non-Lyme Borrelia species, but the incubation period was significantly prolonged. Samples have been sent for molecular Borrelia testing and blood films. Key learning points Rheumatologists are often asked to review patients with recurrent fever. An awareness of atypical infectious differentials can be crucial to making the correct diagnosis. Relapsing fever is an umbrella term used to describe the characteristic pattern of infection cause
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