Phytochemical analysis and in vitro biological activity of Betonica officinalis and Salvia officinalis extracts

摘要

The objectives of this study were to define the phenolic profile, antioxidant, antimicrobial andanti-inflammatory properties of extracts from Betonica officinalis and Salvia officinalis herbs used intraditional medicine. The results indicated that the extract inhibits scavenges stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cationradicals. In the present study, Salvia officinalis was potent antibacterial agent against Staphylococcusaureus, Staphylococcus epidermidis, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa.The extracts inhibited cyclooxygenase (COX-1) and denaturation of protein, which suggests thesespecies might be a potential source of plant-derived anti-inflammatory substances. Our study, for thefirst time, revealed the antimicrobial and anti-inflammatory activity of the Betonica officinalis herb.The results of this study could be helpful to develop medicinal preparations and uses of this species asan antimicrobial, anti-inflammatory and wound healing agent.