Bacteriophages – novel biotechnology tools available in clinical practice in Romania

摘要

Staphylococcus species can be the etiological agents of hard-to-treat infections because oftheir capacity to form biofilm, invade host cells and develop resistance to available antimicrobials.We present the case of a patient who developed periprosthetic dorsolumbarsoft-tissue infection withS. aureus and could not receive effective antibiotic treatment due to a history of multiple drug allergysyndrome. Therapeutic success and eradication of biofilm were obtained by combining topicalbacteriophages with oral antibiotic therapy. Bacteriophages can be a solution, and further in vitro andin vivo studies are needed for improvingthe biotechnology behind drug delivery.