Surface Active Agents as Excipients in Semi-Solid Dosage Forms

摘要

Surface phenomena involve surface tension, adsorption at interfaces, wettability and contact angle as well as adhesive and cohesive forces. This paper focuses on surface tension and factors that affect it. While developing new dosage forms and aiming at improving drug stability and bioavailability, technologists rely on papers concerning surface tension, the application of hydrophilic-lipophilic balance value and the central role of surfactants. Research into surface phenomena improves our understanding of molecular interactions between phase particles. Surfactants have a central role in many surface phenomena. In semisolid preparations the resulting structures are very complex. In this review paper numerous examples of surfactants application in semisolid drug forms are presented with respective evaluation of surfactant type, and hydrophilic-lipophilic balance values.