Aggressive angiomyxoma is a rare type of soft tissue tumour. It has traditionally been described as a low-grade myxomatous neoplasm of the vulvovaginal, perineal and pelvic regions in women, and has a high rate of recurrence because of its infiltrative potential and locoregional extension. Its pathogenesis and histogenesis are poorly understood, but it is proposed that chromosome 12 alterations and fibroblastic/myofibroblastic tumours are involved in its origin. Around 250 cases have been reported to date in the western literature, some of them with unusual presentations. The biggest reported tumour measures 26cm×21cm×6cm. The following article describes two case reports of this neoplasm, which were studied at Mexico's General Hospital “Dr. Eduardo Liceaga” over period of one year. Both case reports state that the tumours are considerably bigger than the ones currently reported (66cm×60cm×20cm and 50cm×46cm×17cm). We shall focus on histopathology and end with an analysis and discussion.
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