The objective of this study was to evaluate the effect of mineral fertilizer NPK associated with the organic waste "poultry litter" on the agronomic characteristics of soybean as well as nutrient levels in the Cambisol. The experiment was carried out in Itutinga, southern Minas Gerais state, Brazil, in a randomized blocks experimental design with three replications in split-plot. The cultivar used was BRS Favorita RR. The treatments applied to plots consisted on four doses of "poultry litter" (0; 3; 6 and 9 Mg ha-1), applied in the total area. The subplots were the five doses of mineral fertilizer NPK 04-30-10 (0; 100; 200; 300 and 400 kg ha-1), applied to the groove seeding. Fertilization with mineral fertilizers provides an increase in plant and first pod height, number of pods per plant and yield of soybean. Fertilization with organic waste "poultry litter" increases the plant and first pod height, weight of 100 grains, number of pods per plant and yield of soybean, however at higher doses favors the lodging of plants. The use of poultry litter is viable in agronomic and economic terms in the soybean crop. The addition of poultry litter increases the contents of potassium and sulfur in the soil.
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