Capillary pCO₂ helps distinguishing idiopathic pulmonary arterial hypertension from pulmonary hypertension due to heart failure with preserved ejection fraction

摘要

RationaleThe demographics of patients with idiopathic pulmonary arterial hypertension (IPAH) are changing and this diagnosis is increasingly being made in older patients. However, diagnostic misclassifications are common as it may be difficult to differentiate between IPAH and pulmonary hypertension due to heart failure with preserved ejection fraction (PH-HFpEF). We investigated the hypothesis that the capillary pCO2 (pcCO2) may help distinguishing between idiopathic pulmonary arterial hypertension (IPAH) and pulmonary hypertension due to heart failure with preserved ejection fraction (PH-HFpEF).MethodsIn a cross-sectional study, we retrospectively assessed pcCO2 levels (obtained from arterialized capillary blood at the time of diagnosis) from patients with IPAH or PH-HFpEF, respectively. Receiver operated characteristics (ROC) were used to determine the pcCO2 level providing the best discrimination between these two conditions. PcCO2 values were considered helpful if they were associated with a negative predictive value >0.9 to excluded either IPAH or PH-HFpEF.ResultsThe study enrolled 185 patients, 99 with IPAH (74% female; age 47?±?17?years; body mass index 26?±?5?kg/m2, PAPm 53?±?12?mmHg, PAWP 8?±?3?mmHg), and 86 with PH-HFpEF (64% female; age 69?±?10?years; body mass index 30?±?6?kg/m2, PAPm 47?±?10?mmHg, PAWP 21?±?5?mmHg). PcCO2 at time of diagnosis was 33?±?4?mmHg in the IPAH group and 40?±?5?mmHg in the PH-HFpEF group (p??41?mmHg.ConclusionsPcCO2 levels were significantly lower in IPAH compared to PH-HFpEF and may provide useful information in differentiating between both conditions.