Neonatal Late-Onset Sepsis in a NICU: Analysis of Causative Organisms and Antimicrobial Susceptibility Ali Asghar Children Hospital from (2004/5-2007/5), Tehran, Iran

摘要

Bacterial sepsis is one of the most common causes of significant mortality and morbidity in neonates. The researchers analyzed bacterial isolates and their antibiotic susceptibilities for cases of septicemia in a Neonatal Intensive Care Unit (NICU) of a teaching hospital in Tehran, Iran. During a 36 months period, the incidence of bacteremia and the causing organisms and mortality of sepsis as well as antibiotic susceptibility were investigated. Neonatal Late-Onset Sepsis (LOS) was defined as clinical signs suggestive of infection with a positive Blood Culture (B/C) after 72 h of birth. About 909 neonates were admitted to the NICU. A total of 9.13% of neonates (83/909) had at least one positive B/C after 72 h of birth. The vast majority (56.6%) of sepsis were caused by Gram-negative organism. Gram-positive pathogens accounted for 41% infections. The most common cause of late-onset sepsis was Klebsiela p. (31%) and followed by Staph aureus (18.1%). In this study, the researchers have observed that the old empiric therapy with cephalothine plus Amikacin for suspected late-onset sepsis seems ineffective. Now, however may be the best choice regimen is the combination vancomycin plus amikacin and the vancomycin plus imipenem for the severe ill patients.