Skin irritation study due to Electron beam cured Polyurethane based Pressure sensitive Adhesive tape in Oryctolagus cuniculus

摘要

Pressure sensitive adhesives (PSAs) have an important role in health care industry and are used in a range of medical applications from low tack PSA tapes to high tack implant adhesives. Biocompatibility of such medical devices is an urgent requirement of many agencies since, used on human body. Therefore, the materials that come in contact must be evaluated and determined to be safe for use, which may leach off of a device into adjacent tissue. Some leachables are not biologically safe and can harm the body after or during application. The study helps to determine whether materials that causes adverse effects, has immense importance before commercialization of product. In the present study an attempt has been made to assess skin irritation of a microporous PSA tape made of polyurethane (PU) acrylate by electron beam (e-beam) irradiation process. The results of the study may help in predicting the irritation potential of the test item in humans or higher mammals.