New 5-oxomilbemycins from a Genetically Engineered Strain Streptomyces bingchenggensis BCJ60

摘要

Two new 5-oxomilbemycins, 27-aldehyde -5-oxo milbemycin β 12 ( 1 ) and 2-hydroxymilbemycin K ( 2 ) , were isolated from a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined by comprehensive analyses of its 1H and 13C NMR, COSY, HMQC, and HMBC spectroscopic, HR - E S I - MS mass spectrometric and comparison with data from the literature . Preliminary studies showed that 27-aldehyde -5-oxo milbemycin β 12 ( 1 ) and 2-hydroxymilbemycin K ( 2 ) possessed strong acaricidal and nematocidal activities.