Antileishmanial Activity of a New ent-Kaurene Diterpene Glucoside Isolated from Leaves of Xylopia excellens R.E.Fr. (Annonaceae)

摘要

This work describes a new ent -kaurene diterpene glucoside, 7 β - O - β -D-glucopyranoside- ent -kaur-16-ene, from the leaves of Xylopia excellens R.E.Fr. (Annonaceae). The compound showed high in vitro antileishmanial activity (IC 50 of 15.23 ± 0.64 μg/mL) towards promastigote forms of Leishmania amazonensis , and low cytotoxicity against J774A1 cells (SI of 1.96).