Influence of obesity and cardiometabolic makers on lipoprotein-associated phospholipase A₂ (Lp-PLA₂) activity in adolescents: the healthy young cross-sectional study

摘要

Background Lipoprotein-associated phospholipase A2 activity (Lp-PLA2) is a good marker of cardiovascular risk in adults. It is strongly associated with stroke and many others cardiovascular events. Despite this, the impact of obesity on this enzyme activity and its relation to biomarkers of cardiovascular disease in adolescents is not very well investigated. The purpose of this article is to evaluate the influence of obesity and cardiometabolic markers on Lp-PLA2 activity in adolescents. Results This cross-sectional study included 242 adolescents (10–19 years) of both gender. These subjects were classified in Healthy Weight (n?=?77), Overweight (n?=?82) and Obese (n?=?83) groups. Lipid profile, glucose, insulin, HDL size, LDL(?) and anti-LDL(?) antibodies were analyzed. The Lp-PLA2 activity was determined by a colorimetric commercial kit. Body mass index (BMI), waist circumference and body composition were monitored. Food intake was evaluated using three 24-hour diet recalls. The Lp-PLA2 activity changed in function to high BMI, waist circumference and fat mass percentage. It was also positively associated with HOMA-IR, glucose, insulin and almost all variables of lipid profile. Furthermore, it was negatively related to Apo AI (β?=??0.137; P?=?0.038) and strongly positively associated with Apo B (β?=?0.293; P?