Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling

摘要

In this case report, we describe a refractory CMML case without eosinophilia harboring a PDGFRB rearrangement leading to a favorable response with imatinib. We believe this case demonstrates the utility of broad spectrum genomic profiling in refractory CMML cases as an opportunity to uncover additional treatment options.