Mass urbanisation presents one of the most urgent challenges of the 21st century. The development of cities and the related increasing ground sealing are asking even more for the restoration of urban rivers, especially in the face of climate change and its consequences. This paper aims to demonstrate nature-inspired solutions in a recovery of a Southern European river that was canalised and transformed in culvert pipes. The river restoration project naturally tells the history of the city, creates a sense for the place, as well as unifying blue–green infrastructure in a symbolic way by offering areas for recreation. To improve well-being and city resilience in the long term, a regenerative sustainability approach based on biophilic design patterns was proposed. Such actions will provide greater health, social cohesion, and well-being for residents and simultaneously reduce the risks of climate change, such as heat island effect and flash floods, presenting the benefits of the transition to a regenerative economy and holistic thinking.
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