Failure of ethanol and phenobarbitone to reduce organochlorine pesticide residues in sheep

摘要

The concentration of pp'DDT, pp'DDE, pp'DDD, and op'DDT in the fat and blood of sheep was determined for 24 weeks after a single administration of technical DDT (50 mg/kg b.w.); op'DDT and pp'DDD were eliminated more rapidly than pp'DDT. The most marked feature was the persistence of pp'DDE, which increased and then remained at a plateau level throughout the experiment. Oral administration of ethanol for 4 weeks, and of parenteral phenobarbitone for 12 weeks, produced no apparent change in the residue levels.