Comparison of antibacterial and antifungal activity of 5-amino-2-mercapto benzimidazole and functionalized Ag3O4 nanoparticles

摘要

The work focused on the antibacterial and antifungal effect of 5-amino-2-mercapto benzimidazole (AMB), non-functionalized and functionalized Ag 3 O 4 nanoparticles. The synthesized non-functionalized (n-Ag 3 O 4 ) and functionalized (f-Ag 3 O 4 ) nanoparticles particle sizes measured 18.72 and 29.11?nm respectively. The XRD results of samples exhibit shift in 2θ values of most prominent peaks due to surface functionalization of Ag 3 O 4 nanoparticles with AMB. The surface functionalization of AMB on Ag 3 O 4 nanoparticles further studied with FT-IR studies, which show the effective binding site is azomethine nitrogen evidenced from the shift of bands at 1635 and 1615?cm ?1 in n-Ag 3 O 4 nanoparticles to lower frequency region at 1629 and 1597?cm ?1 in f-Ag 3 O 4 nanoparticles. The functionalization of Ag 3 O 4 nanoparticles and surface morphology further confirmed with HR-SEM with EDAX results. The antimicrobial effect of the non-functionalized and functionalized Ag 3 O 4 nanoparticles dispersed in water was investigated. Antimicrobial activities were evaluated against bacterial strain of Pseudomonas aeruginosa , Staphylococcus aureus , and fungi Aspergillus niger used in this work. The n-Ag 3 O 4 nanoparticles exhibit excellent antibacterial and antifungal effect compared to f-Ag 3 O 4 nanoparticles and AMB. The decreased effect of f-Ag 3 O 4 nanoparticles is might be due to increase in particle size and the interaction of silver oxide nanoparticles with bacteria membrane and intracellular proteins decreases with functionalization. Graphical abstract Display Omitted.