SAT-329 EARLY LIFE FACTORS AND LONGITUDINAL BLOOD PRESSURE TRAJECTORIES ARE ASSOCIATED WITH ELEVATED BLOOD PRESSURE IN EARLY ADULTHOOD: BIRTH TO TWENTY PLUS COHORT

摘要

Evidence from both human and animal studies indicate that blood pressure responses to sodium (Na*) administration are dependent on the anion present with sodium, and that sodium bicar- bonate (NaHCO3) promotes hypertension to a lesser degree than sodium chloride (NaCl). Recent advances implicate the immune system in the development of salt-sensitive hypertension. Specifically, Na loading has been reported to activate pro-inflammatory Th17 T-lymphocytes (T-cells) over anti-inflammatory regulatory T-cells (Tregs). It remains unclear however, if initiation of a diet with increased NaCl promotes a greater pro-hypertensive inflammatory response compared to NaHCO; loading. We hypothesized that initiation of NaCl loading in rats promotes a greater pro-inflammatory T-cell response when compared to NaHCO .