SAT-010 PROTECTIVE EFFECTS OF SPARSENTAN FROM PROLIFERATIVE GLOMERULAR INJURY INDUCED BY ADMINISTRATION OF HUMAN IMMUNE COMPLEXES IN A MURINE MODEL OF EXPERIMENTAL IgA NEPHROPATHY

摘要

Bioinformatics analyses were performed to identify and rank the bio- markers based on their sensitivity and specificity. expression in MN serum when compared to controls (see table 1). Mx1, a GTPase commonly involved downstream of the type I IFN pathway and associated with antiviral activity, has been found to be upregulated in lupus nephritis and its association with MN warrants further investigation. The presence of EEFIG in MN patients correlate to MN murine mice model studies that have shown dif- ferential expression of EEFIG, specifically subunit alpha, in MN kidney tissue when compared with normal kidneys. GSK3B, which has been found to be associated with diabetic nephropathy through microRNA and haplotype association studies, was prominently elevated in MN patients with diabetes versus diabetes alone and may be useful in the stratification between membranous nephropathy and diabetic nephropathy. Conclusions: From this pilot study, we have found a panel of potential candidate proteins that can be further studied in a larger scale protein profiling study which can eventually lead to the discovery of more specific biomarkers which can act as a management adjunct by accu- rately diagnosing, prognosticating and aid in treatment of MN.