Synthesis and Cytotoxicities of Royleanone Derivatives

摘要

Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11–C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro. Electronic supplementary material The online version of this article (10.1007/s13659-018-0173-y) contains supplementary material, which is available to authorized users.