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首页> 外文期刊>Morbidity and Mortality Weekly Report: CDC Surveillance Summaries >Notes from the Field: Domestically Acquired Verona Integron-Mediated Metallo-?2-Lactamase-Producing Enterobacteriaceae a?? Indiana, 2016a??2017
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Notes from the Field: Domestically Acquired Verona Integron-Mediated Metallo-?2-Lactamase-Producing Enterobacteriaceae a?? Indiana, 2016a??2017

机译:实地记录:国产维罗纳整合素介导的产金属-β2-内酰胺酶的肠杆菌科印第安纳州,2016a ?? 2017

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Beginning in January 2016, Verona integron-mediated metallo-β-lactamase (VIM) producing carbapenem-resistant Enterobacteriaceae (CRE) were identified in Indiana. CRE are an emerging antibiotic-resistant public health threat. CRE spread might be largely due to the emergence of carbapenemase-producing CRE (CP-CRE). Carbapenemases are generally encoded on mobile genetic elements that are easily transferred between bacterial strains, greatly increasing their potential for spread (1–3). Furthermore, CP-CRE pose a risk because of their extensive drug resistance, increased associated mortality, and national lack of public health laboratory capacity for detection prior to 2016 (2,4,5).
机译:从2016年1月开始,在印第安纳州发现了维罗纳整合素介导的金属β-内酰胺酶(VIM)产生耐碳青霉烯的肠杆菌科(CRE)。 CRE是新兴的耐药性公共卫生威胁。 CRE的传播可能很大程度上是由于产生碳青霉烯酶的CRE(CP-CRE)的出现。碳青霉烯酶通常编码在可轻易在细菌菌株之间转移的移动遗传元件上,从而大大增加了其传播的可能性(1-3)。此外,由于CP-CRE广泛的耐药性,相关的死亡率增加以及2016年之前全国公共卫生实验室缺乏检测能力,因此存在风险(2、4、5)。

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